Home > Academic Announcements > (Jun. 15) Frontiers in Medical Sciences Lecture 336-Human 3D Genome Organization, Evolution and Disease

(Jun. 15) Frontiers in Medical Sciences Lecture 336-Human 3D Genome Organization, Evolution and Disease

Last updated :2018-06-14

Topic: Human 3D genome organization, evolution and disease
Speaker: Dr. Zhonghui Tang
Host:
Bo Li, Professor, Zhongshan School of Medicine, SYSU
Time: 10:00-12:00, Friday, June 15, 2018
Venue: Room Boai, Science Building, Zhongshan School of Medicine, Guangzhou North Campus, SYSU

About the speaker:
Dr. Tang mainly engaged in the research of 3D genome structure and function by using leading-edge three-dimensional genome analysis technology (ChIA-PET, HiC) and bioinformatics multi-omics data integration analysis. Using 3D genome analysis technology to study the 3D genome of humans and mice, to reveal the molecular mechanism of gene expression in the 3D genome using remote transcription regulatory elements, and to clarify the spatial relationship between chromatin spatial structure and gene transcription. Explaining changes in SNPs in non-coding regions of proteins leads to structural changes in chromatin spatial interactions, leading to abnormal gene expression regulation, which may lead to the development of related diseases. Dr. Tang obtained many innovative research achievements in the field of 3D genomes, published two research papers in Cell magazine as the first and co-first authors, published a paper in Genome Research magazine, and published research in Cell and Nature as co-authors. Dr. Tang’s research achievements in the field of 3D genomics provide a new perspective on understanding the mechanism of gene expression regulation based on the three-dimensional structure of chromatin space, understanding the relationship between genome structure variation, evolution and disease occurrence, and providing new research ideas for precision medicine.